Stomach Cancer: Understanding, Diagnosing, and Treating Effectively

Overview

Globally, stomach cancer, also known as gastric cancer, is a significant health concern, with over one million new cases diagnosed annually. Ranking as the 5th most commonly diagnosed and the 7th most prevalent cancer worldwide, it presents a notable risk throughout an individual’s lifetime, particularly in males. Understanding the causes, symptoms, and treatment options can be a vital step in early detection and successful management.

Causes and Types

Stomach cancer emerges when the normal cells in the stomach undergo abnormal transformations and proliferate uncontrollably. The types of stomach cancer vary, depending on the specific cells and regions of the stomach involved. One of the known precursors to stomach cancer is an infection with the bacteria H. pylori, which can affect the stomach and intestines, potentially leading to symptoms like abdominal pain, bloating, and nausea. If left untreated, this infection can escalate to stomach cancer.

Clinical Presentation

In its initial stages, stomach cancer may not manifest any noticeable symptoms. However, as it progresses, individuals might experience:

  • Significant weight loss
  • Upper abdominal pain
  • Difficulty swallowing
  • Loss of appetite or feeling full quickly
  • Nausea
  • Fatigue or breathlessness due to anemia

Diagnostic Procedures

Diagnosing stomach cancer involves a series of tests, including:

  • Upper Endoscopy: A primary diagnostic tool where a thin tube equipped with a camera and light is inserted through the mouth to examine the stomach lining.
  • Biopsy: Conducted during an upper endoscopy, it involves extracting a tissue sample from the stomach for microscopic examination.
  • Blood Tests: To assess the overall health and to detect markers of cancer.
  • Imaging Tests: Such as CT scans, to create detailed pictures of the stomach’s interior and identify any abnormalities.

Treatment Approaches

Treatment for stomach cancer is multi-faceted, encompassing various strategies such as:

  • Surgery: Involves the partial or complete removal of the stomach, followed by the reconnection of the digestive tract to facilitate eating.
  • Chemotherapy: Utilizes medications to target and eliminate cancer cells or inhibit their growth, sometimes administered before surgery to shrink the tumor.
  • Radiation Therapy: A method that employs radiation to destroy cancer cells effectively.
  • Immunotherapy: Engages the body’s immune system to halt the progression of cancer.

Integrative Medicine for Stomach Cancer

In addition to conventional treatments, integrating complementary therapies can enhance the effectiveness of the treatment plan. Here are some integrative treatments justified for use in stomach cancer patients:

  • Autologous Immunotherapy: Utilizes the patient’s immune cells to target and eliminate cancer cells, enhancing the body’s natural defense mechanisms.
  • Pharmacological Immunotherapy: Involves the use of drugs to boost the immune system’s ability to fight cancer cells, offering a targeted approach to cancer treatment.
  • Dendritic Enhancers: These are used to boost the immune response by enhancing the function of dendritic cells, which play a crucial role in immune responses.
  • Systemic Perfusion Hyperthermia: A treatment method that uses heat to increase the vulnerability of cancer cells to other treatments, enhancing the effectiveness of primary therapies.
  • Mistletoe: Used as a complementary therapy, mistletoe can help improve symptoms and enhance the quality of life in cancer patients.
  • Glutathione: A powerful antioxidant that helps protect cells from damage, playing a protective role in cancer treatment.
  • Personalized Nutrition: Tailoring nutrition plans to the individual needs of the patient, supporting overall health and well-being during cancer treatment.
  • Vitamin D IV: Administered intravenously, it helps in enhancing the immune response and may have protective effects against cancer.
  • Zinc: An essential mineral that plays a role in immune function and may help in improving the response to cancer treatment.
  • Melatonin: A hormone that can help in managing sleep disturbances in cancer patients, enhancing the quality of life.
  • Curcumin: A compound found in turmeric, it has anti-inflammatory and antioxidant properties, potentially offering protective effects against cancer.
  • Sylimarin: A compound found in milk thistle, it has antioxidant properties and may help in protecting liver function during cancer treatment.
  • Vitamin E: A potent antioxidant that helps in protecting cells from damage, supporting overall health during cancer treatment.

By incorporating these integrative treatments, patients can experience a more holistic approach to cancer care, potentially enhancing the effectiveness of conventional treatments and improving the quality of life.

Immunotherapy

The goal of cancer immunotherapy is to improve the body natural ability to find and destroy cancer cells. Successful immunotherapeutic approaches stimulate the natural defenses of the immune system and provide new ways to attack cancer. This is possible with comprehensive interventions that include cell therapy / immuno-pharmacological therapy in combination with nutritional, endocrine measures and supplements.

Vaccines

Cancer vaccines deliver a cancer-specific protein to the body and direct the immune system to target cells that contain that protein.
Chimeric antigen receptor (CAR)-modified T-cell immunotherapy involves taking the patient’s Tcells, genetically engineering the T cells to produce receptors that direct them to the cancer cells, and returning these CAR T cells to the patient’s body (NCI 2017b).

Dendritic enhancer or T-cell modulators

T-cell Modulators are peptide chains composed of tens of amino acids that appear to store all the experience of the immune system. The great intellectual leap to understand is that T-cell Modulators do not transfer antibodies nor create them directly, but its function is to educate, and teach the immune cells to recognize specific antigens that could happen to them unnoticed T-cell Modulators do not cure anything but work to make a “smarter” immune system so that it is the body itself eliminating disease. They are therefore vital in developing the strategies of the immune system against cancer.
T-cell Modulators contains several immunoactive components that have been shown to act synergistically in raising Dendritic and NK function.

Hyperthermia

Hyperthermia involves the use of heat to directly treat a tumor or increase the vulnerability of cancer cells to other forms of treatment, such as immunotherapy, B17, vitamin C, chemotherapy or radiotherapy.

Non-ablative or mild hyperthermia (HT) has been shown in preclinical and clinical studies as a localized sensitizer that enhances the tumoricidal effects of immunotherapy, radiation or chemotherapy.

A novel, minimally invasive interventional technique, HT has been shown to improve the efficacy of chemotherapy and immunotherapy for solid organ tumors.

Liposomal Mistletoe

Mistletoe helps fight tumor-induced immune suppression. Natural killer cells (NK) are a type of white blood cell that looks for and destroys cancer cells. Studies show that it activates natural killer cells, T cells, macrophages and monocytes.

A study involving 220 cancer patients showed that those given mistletoe experienced less fatigue, insomnia, anorexia, and nausea. For stomach cancer, adding mistletoe to an oral chemotherapy regimen may also be beneficial.

Gluthatione

Glutathione is the most important antioxidant produced by your body and a master detoxifier of every cell in your body. It prevents cellular damage caused by free radicals and peroxides.

Glutathione metabolism can play both protective and pathogenic roles. It is crucial in the removal and detoxification of carcinogens, and alterations in this pathway can have a profound effect on cell survival. However, by conferring resistance to several chemotherapeutic drugs, elevated levels of glutathione in tumor cells can protect such cells.

Vitamin D

Background and Objectives Vitamin D deficiency is linked to several gastrointestinal malignancies including gastric cancer and affects a multitude of cellular processes involved in tumorigenesis.

Vitamin D, extensive literature demonstrates its action as a preventive agent and treatment of immunological abnormalities.

Melatonin

Melatonin, a hormone best known for its role in regulating sleep, is also emerging as a promising anti-cancer agent. Evidence to date has shown that melatonin can interfere with cancer initiation, progression, and metastasis.

Melatonin Inhibits the Proliferation of Gastric Cancer Cells Through Regulating the miR-16-5p-Smad3 Pathway.

Diseases Treated at Integrative Immunotherapy Institute

Adenocarcinoma
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Soft Tissue Sarcoma
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